This paper is a review on the chemical constituents and biological activities of the fruiting bodies of seven edible and two inedible mushrooms with reported anticancer properties found in the Philippines. We previously reported the chemical constituents of the dichloromethane extracts of the fruiting bodies of these mushrooms, which were cultured at Central Luzon State University, bought from the Mushroom Burger and Metro Manila supermarkets, and collected from Mt. Makiling. These studies yielded ergosterol (1) ergosterol peroxide (2) cerevisterol, di linoleoyl oleoylglycerol, and a mixture of linoleic acid (3) palmitic acid, stearic acid and oleic acid from Pleurotus florida; 1, triacylglycerols (4) and fatty acid methyl esters from Pleurotus djamor; 1 and 4 from Flammulina velutipes; 1 and trilinolein (5) from Pleurotus eryngii and Lentinula edodes; 1, 3, 5 and brassicasterol from Agaricus bisporus; 2 from Auricularia auricula-judae; 2-4 and 3β-linoleyloxyergosta-7,22-diene from Coprinopsis lagopus; and 2 and 4 from Phellinus gilvus (Schwein.) Pat. Compounds 1–5 were reported to exhibit anticancer properties, which may contribute to the anticancer activities of these mushrooms. Other studies revealed that the anticancer principles of some of these mushrooms are polysaccharides and proteins.
Keywords: Pleurotus florida, Pleurotus djamor, Flammulina velutipes, Pleurotus eryngii, Lentinula edodes, Coprinopsis lagopus, Phellinus gilvus, Agaricus bisporus, Auricularia auricula-judaeAkamatsu, S., Watanabe, A., & Tamesada, M. (2004). Hepatoprotective effect of extracts from Lentinus edodes mycelia on dimethylnitrosamine-induced liver injury. Biological and Pharmaceutical Bulletin, 27, 1957–1960.
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