Syzygium samarangense (Jambu) is a tropical fruit that is nutritionally and medicinally important and that has been consumed in Southeast Asian countries for decades. Unfortunately, the fruits accumulate pesticide residues due to their agricultural production. Consequently, this results in health issues such as congenital diseases and cancers. For this reason, the QuEChERS-dSPE ionic-liquid-based dispersive liquid–liquid microextraction method coupled with high-performance liquid chromatography–tandem mass spectrometry was used for the determination of multiple pesticide residues (propamocarb, carbaryl, Baycarb, thiobencarb, metalaxyl, thiamethoxam, diazinon, and chlorpyrifos) in a red Syzygium samarangense sample. The results show that accuracy (88%–106%) and precision (1%–14%) ranges were satisfactory because they were within recommended ranges: 70%–120% and ≤20%, respectively. The method limit of detection and limit of quantitation range results were satisfactory: 0.02–0.17 μg/kg and 0.06–0.56 μg/kg, respectively. The linearity range (5–400 μg/kg) results were linear with a coefficient of regression (R2) greater than 0.999. The matrix effect results were very weak, being ≤−86%. The measurement of uncertainty range results (4%–19%) were satisfactory as recommended (≤50%). Therefore, the sample preparation technique proved reliable for routine determination of pesticide multiresidue in Syzygium samarangense. Also, the consumption of Syzygium samarangense from the sourced area is justified based on the obtained concentration levels of pesticide residues in the blank sample, which were lower than European Union maximum residue limits.
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